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The site of sphingomyelin synthesis in the rapidly growing Morris hepatomas 7777 and 5123D was determined by incubating plasma membrane, mitochondrial and microsomal membrane fractions with vesicles of phosphatidyl[methyl-14C]choline in the presence of phosphatidylcholine transfer protein. In agreement with a previous study on rat liver (Voelker, D.R. and Kennedy, E.P., 1982, Biochemistry 21, 2753-2759) we have demonstrated that sphingomyelin synthesis in these hepatomas is restricted to the plasma membrane. The greatly elevated sphingomyelin content of mitochondria and microsomes (Hostetler, K.Y., Zenner, B.D. and Morris, H.P., 1979, Cancer Res. 39, 2978-2983) suggests that rapidly growing hepatomas, in contrast to liver, have an effective mechanism of intracellular sphingomyelin transfer.
A van den Hill, and
G P van Heusden, and
K W Wirtz
January 1984,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
A van den Hill, and
G P van Heusden, and
K W Wirtz
January 1976,
Folia histochemica et cytochemica,
A van den Hill, and
G P van Heusden, and
K W Wirtz
February 1976,
Biochimica et biophysica acta,
A van den Hill, and
G P van Heusden, and
K W Wirtz
January 1970,
Cancer research,
A van den Hill, and
G P van Heusden, and
K W Wirtz
January 1983,
Patologia polska,
A van den Hill, and
G P van Heusden, and
K W Wirtz
January 1977,
Oncology,
A van den Hill, and
G P van Heusden, and
K W Wirtz
March 1978,
European journal of biochemistry,
A van den Hill, and
G P van Heusden, and
K W Wirtz
February 1978,
European journal of biochemistry,
A van den Hill, and
G P van Heusden, and
K W Wirtz
January 1980,
Neoplasma,
A van den Hill, and
G P van Heusden, and
K W Wirtz
September 1982,
The Journal of surgical research,
