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The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(I,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(I,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(I,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a debulking regimen it resulted in increased survival with protocols in which poly(I,C)-LC alone was insufficient. These data suggest that the systemic administration of poly(I,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
January 1987,
Pathology and immunopathology research,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
February 1978,
Antimicrobial agents and chemotherapy,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
December 1985,
Journal of biological response modifiers,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
January 1981,
International journal of immunopharmacology,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
July 1986,
Gynecologic oncology,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
November 1986,
Cancer treatment reports,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
November 1992,
International journal of immunopharmacology,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
June 1992,
Cancer research,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
October 1990,
Japanese journal of medical science & biology,
J E Talmadge, and
J Adams, and
H Phillips, and
M Collins, and
B Lenz, and
M Schneider, and
M Chirigos
January 2015,
Vaccine,
