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The metabolism of pyrimidine nucleosides present in the plasma of the mouse has been examined. Uridine and cytidine are rapidly cleared from the circulation with t1/2 of less than 5 min. Uracil, deoxycytidine, deoxyuridine, and thymidine are cleared more slowly with t1/2 of 9 to 13 min. Various tissues differed markedly in the extent of nucleotide formation from circulating nucleosides. Cytidine and uridine are predominantly converted to nucleotides (greater than 50%) rather than catabolized, whereas uracil is almost entirely degraded. Thymidine, deoxyuridine, and deoxycytidine are intermediate in the extent of their conversion to nucleotides: 8.9 to 21% of these nucleosides are salvaged in the mouse. Both anabolic and catabolic routes are important in the metabolism of pyrimidine nucleosides in vivo.
J D Moyer, and
N Malinowski, and
O Ayers
August 1981,
Cancer research,
J D Moyer, and
N Malinowski, and
O Ayers
February 1984,
Molecular and biochemical parasitology,
J D Moyer, and
N Malinowski, and
O Ayers
November 1983,
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire,
J D Moyer, and
N Malinowski, and
O Ayers
September 1978,
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J D Moyer, and
N Malinowski, and
O Ayers
January 1959,
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J D Moyer, and
N Malinowski, and
O Ayers
August 1975,
Annals of the New York Academy of Sciences,
J D Moyer, and
N Malinowski, and
O Ayers
May 1929,
Science (New York, N.Y.),
J D Moyer, and
N Malinowski, and
O Ayers
April 1969,
Chemical & pharmaceutical bulletin,
J D Moyer, and
N Malinowski, and
O Ayers
August 1974,
Biochimica et biophysica acta,
J D Moyer, and
N Malinowski, and
O Ayers
January 1976,
Cancer research,
