The level of antibody to pneumococcal 19F polysaccharide (PS) was studied in the serum of mice inoculated with klebsiella K2 PS or pneumococcal 19F PS or both. The serum antibody levels and the IgM plaque-forming-cell (PFC) response after immunization were higher in mice given both K2 PS and 19F PS than in mice of a control group given 19F PS alone. This immune response was also higher than the sum of PFC production in mice given 19F PS or K2 PS separately. Thus, K2 PS produced the cross-reactive antibody to 19F PS and also enhanced the magnitude of the antibody response to 19F PS. This response appeared to be specific for the 19F PS. The resulting high levels of antibody to pneumococcal 19F persisted for eight weeks after the administration of K2 PS and 19F PS. Animals immunized with both type 3 PS and K2 PS did not show an increased antibody response to pneumococcal type 3 PS. Klebsiella K-O3 antigen also stimulated the immune response to 19F PS. Higher immunologic responses to 19F PS were also induced in nude mice injected with the cross-reacting K2 PS or K47 PS and 19F PS. The ability to stimulate an antibody response to 19F PS by administering both K2 PS and 19F PS could not be transferred with spleen cells obtained from mice given both K2 PS and 19F PS.