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Several laboratories have reported that exposure of cells to UV radiation results in a significant imbalance in deoxynucleoside triphosphate pool concentrations. In our CHO-K1 cells, a rapid drop in dCTP is accompanied by a rapid increase in dTTP. Examination of enzyme activities associated with synthesis/degradation of these molecules suggests that UV transiently enhances a putative dCTPase, dCMP deaminase and CdR kinase activities. This results in accumulation of excess dUMP which is probably converted to dTMP, then to dTTP. The absence of dCMP deaminase in V79 cells prohibits this rapid response in those cells. Moreover, significantly different dCMP deaminase activities were observed in CHO-K1 cells obtained from other laboratories, suggesting they, too, may respond differently to irradiation.
C N Newman, and
J H Miller
September 1984,
Biochemical and biophysical research communications,
C N Newman, and
J H Miller
December 1983,
Mutation research,
C N Newman, and
J H Miller
January 1984,
Mutation research,
C N Newman, and
J H Miller
January 1988,
Mutation research,
C N Newman, and
J H Miller
January 1993,
Nucleic acids symposium series,
C N Newman, and
J H Miller
February 2006,
The Journal of biological chemistry,
C N Newman, and
J H Miller
August 1984,
Biochemical and biophysical research communications,
C N Newman, and
J H Miller
January 1998,
Apoptosis : an international journal on programmed cell death,
C N Newman, and
J H Miller
December 2003,
Environmental toxicology,
C N Newman, and
J H Miller
February 1980,
Mutation research,
