Biomaterial Database

Pre- and postsynaptic actions of tetraethylammonium at the chick neuromuscular junction. 1985

F A Wali

The possible pre- and postsynaptic effects of tetraethylammonium (TEA; a potassium ion channel blocker) have been examined in the isolated chick neuromuscular junction. The presynaptic effect of TEA was studied by investigating its effect on the uptake of tritiated choline, 3H-methyl choline, which was taken as an index of acetylcholine (ACh) release. The postsynaptic effect of TEA was investigated using solutions containing no calcium ions and/or calcium antagonist lanthanum. TEA increased the uptake of tritiated choline by a factor of 10. Although the contracture produced by TEA was greatly reduced by lanthanum (0.1-1 microM), it still persisted in the calcium-free Krebs solution.

UI	MeSH Term	Description	Entries
D007811	Lanthanum	The prototypical element in the rare earth family of metals. It has the atomic symbol La, atomic number 57, and atomic weight 138.91. Lanthanide ion is used in experimental biology as a calcium antagonist; lanthanum oxide improves the optical properties of glass.
D009469	Neuromuscular Junction	The synapse between a neuron and a muscle.	Myoneural Junction,Nerve-Muscle Preparation,Junction, Myoneural,Junction, Neuromuscular,Junctions, Myoneural,Junctions, Neuromuscular,Myoneural Junctions,Nerve Muscle Preparation,Nerve-Muscle Preparations,Neuromuscular Junctions,Preparation, Nerve-Muscle,Preparations, Nerve-Muscle
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D002794	Choline	A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.	Bursine,Fagine,Vidine,2-Hydroxy-N,N,N-trimethylethanaminium,Choline Bitartrate,Choline Chloride,Choline Citrate,Choline Hydroxide,Choline O-Sulfate,Bitartrate, Choline,Chloride, Choline,Choline O Sulfate,Citrate, Choline,Hydroxide, Choline,O-Sulfate, Choline
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013757	Tetraethylammonium Compounds	Quaternary ammonium compounds that consist of an ammonium cation where the central nitrogen atom is bonded to four ethyl groups.	Tetramon,Tetrylammonium,Compounds, Tetraethylammonium
D019789	Tetraethylammonium	A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)	Tetraethylammonium Chloride,Tetraethylammonium Ion,Tetraethylammonium Bromide,Tetraethylammonium Hydroxide,Tetraethylammonium Iodide,Bromide, Tetraethylammonium,Chloride, Tetraethylammonium,Hydroxide, Tetraethylammonium,Iodide, Tetraethylammonium,Ion, Tetraethylammonium