-transparent.png){kind=logo}
Theophylline clearance was measured at 3 doses (2, 4 and 6 mg/kg) in 10 young, healthy adult subjects. Clearance decreased as the dose of theophylline increased going from 0.064 +/- 0.016 to 0.052 +/- 0.011 1.h-1.kg-1 at the 2 and 6 mg/kg doses, respectively (p less than 0.02). A simplified method for estimating theophylline clearance was tested using single plasma concentrations of theophylline and assuming a constant value (0.5 l/kg) for volume distribution of theophylline. This method gave the best results when samples were drawn at 12 or 24 h after a 2 or 4 mg/kg intravenous dose of theophylline, respectively, and was effectively applied in estimating the quantitative impact of cimetidine administration on theophylline clearance.
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
May 1981,
Thorax,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
August 1984,
Archives of disease in childhood,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
October 1986,
The Journal of allergy and clinical immunology,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
June 1989,
Digitale Bilddiagnostik,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
January 1982,
The Journal of pharmacy and pharmacology,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
January 1979,
Clinical pharmacokinetics,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
January 1985,
Clinical pharmacy,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
July 1987,
Journal of pharmaceutical sciences,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
January 1983,
European journal of clinical pharmacology,
K Bachmann, and
J Schwartz, and
R Forney, and
L Jauregui
January 1987,
Allergologia et immunopathologia,
