-transparent.png){kind=logo}
Although antibody diversity arises mainly from apparently random combinatorial and somatic mutational mechanisms acting upon a limited number of germline antibody genes, the antibody repertoire develops in an ordered fashion during mammalian ontogeny. A series of early pre-B and B-lymphocyte cell lines were examined to determine whether an ordered rearrangement of gene families of the variable region of immunoglobulin heavy chains (VH) may be the basis for the programmed development of the antibody response. The results indicated that the VH repertoire of fetal B-lineage cells is largely restricted to the VH 7183 gene family and that subsequent recruitment of additional VH gene families occurs during neonatal development. These results have important implications in understanding the ontogeny of immune function.
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
February 1985,
Cell,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
January 1984,
Developmental and comparative immunology,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
July 1981,
Nature,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
January 1990,
Molecular immunology,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
April 1984,
Proceedings of the National Academy of Sciences of the United States of America,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
October 1989,
Current opinion in rheumatology,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
September 1990,
Molecular immunology,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
September 1982,
Proceedings of the National Academy of Sciences of the United States of America,
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
January 2012,
Journal of immunology (Baltimore, Md. : 1950),
R M Perlmutter, and
J F Kearney, and
S P Chang, and
L E Hood
November 1999,
Clinical immunology (Orlando, Fla.),
