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The effect of the antibiotic drug amoxicillin on steady state pharmacokinetics of theophylline was studied in healthy adults by comparing the pharmacokinetic parameters as found during a 9 day course of theophylline alone and as obtained during comedication with amoxicillin. Theophylline plasma concentrations were measured by means of h.p.l.c. analysis. On the ninth day of each of the two periods of drug administration a concentration-time curve was evaluated. It showed no influence of amoxicillin on absorption, elimination and volume of distribution of theophylline, as a result of which mean steady state plasma concentrations were not significantly different during both treatments. It is concluded that both drugs can be given concomitantly without any dosage adjustment of theophylline.
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
December 1988,
British journal of clinical pharmacology,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
July 1991,
British journal of clinical pharmacology,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
January 1987,
Chemotherapy,
J H Jonkman, and
W J van der Boon, and
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J Hempenius
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European journal of clinical pharmacology,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
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J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
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J Hempenius
May 1999,
The Journal of antimicrobial chemotherapy,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
August 1990,
Pharmacology & toxicology,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
January 1989,
Biopharmaceutics & drug disposition,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
January 1989,
European journal of clinical pharmacology,
J H Jonkman, and
W J van der Boon, and
R Schoenmaker, and
A Holtkamp, and
J Hempenius
March 1989,
British journal of clinical pharmacology,
