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Eleven surgical pathologists studied microscopic sections from 45 mastectomy specimens of node positive breast cancer patients who had been entered into ECOG clinical trials. Inter-observer reproducibility for histoprognostic features was examined as a prerequisite before a subsequent evaluation of their possible clinical applicability could be undertaken. Histological type, nuclear grade, tubular formation, and lymphoid reactions were studied in the cancerous tissues. Lymph nodal responses (follicular and pulp prominence, sinus histiocytosis) were also examined in a manner that stimulated slide review in routine surgical pathology practice. Numerous two-way comparisons of the pathologists' findings resulted in low levels of agreement (usually much less than 90%). The degree of inter-observer reliability is clinically unacceptable using customary slide review analysis. New ways of examining breast cancer tissues need to be explored in the search for prognostic features which can be applied to the clinical management of breast cancer patients.
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
January 2023,
Skin appendage disorders,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
December 2012,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
January 2015,
PloS one,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
February 2006,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
January 2018,
Indian journal of pathology & microbiology,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
December 1990,
Pathology, research and practice,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
January 2021,
Journal of pathology and translational medicine,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
February 2020,
Breast (Edinburgh, Scotland),
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
November 2005,
Journal of clinical pathology,
K W Gilchrist, and
L Kalish, and
V E Gould, and
S Hirschl, and
J E Imbriglia, and
W M Levy, and
A S Patchefsky, and
D W Penner, and
J Pickren, and
J A Roth
September 2022,
Endocrine pathology,
