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Studies performed on 18 patients with Parkinson's disease and 6 control subjects have shown that acute administration of L-DOPA in clinically effective doses gives rise to a diffuse increase in regional cerebral blood flow without accompanying stimulation of regional oxygen utilization. The data suggest that this rise in rCBF is caused by vasodilatation due to a direct action of the drug on the cerebral blood vessels. The effect of L-DOPA on rCBF did not correlate with the degree of clinical improvement seen in each patient after treatment. The therapeutic effect of L-DOPA in the brain was not reflected in any change of regional cerebral oxygen utilization as measured by our technique. We suggest that the pharmacological actions of L-DOPA in the brain take place on at least two different levels.
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
October 1988,
No to shinkei = Brain and nerve,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
November 1994,
Rinsho shinkeigaku = Clinical neurology,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
August 1999,
Journal of the neurological sciences,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
May 2012,
NeuroImage,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
June 1979,
Archives of neurology,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
March 1996,
The International journal of neuroscience,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
January 1988,
Journal of the neurological sciences,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
June 2017,
Experimental neurology,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
April 1983,
Nihon Ika Daigaku zasshi,
K L Leenders, and
L Wolfson, and
J M Gibbs, and
R J Wise, and
R Causon, and
T Jones, and
N J Legg
August 1992,
Rinsho shinkeigaku = Clinical neurology,
