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Histopathological analyses of brains of rats receiving a single 0.9 LD50 injection of soman, a potent anticholinesterase neurotoxin, revealed massive widespread lesions in the cerebral cortex and thalamus 4 weeks post-injection. Such lesions were not evidenced in rats receiving diazepam (2.2 mg/kg, i.m.) 10 min prior to soman treatment. Thus, anticonvulsant antidotes may aid in preventing extensive or permanent brain damage in rats surviving near-lethal soman dosages.
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