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We studied variables known to change with thyroid hormone status in 18 patients with subclinical hypothyroidism before and during treatment with thyroxine in a dose sufficient to restore the plasma TSH response to TRH to normal. There was an associated increase in both plasma total T4 and free T4 within the normal range but plasma total T3 and free T3 were unchanged. As a result of thyroxine treatment there was a small but significant increase (P less than 0.05) in left ventricular ejection fraction (LVEF) with maximal exercise but no significant changes in LVEF at rest and moderate exercise, continuously monitored mean sleeping heart rate, day/night ratios of urinary sodium excretion, peripheral nerve conduction velocities, fasting serum triglycerides, total cholesterol (TC), high density lipoproteins (HDL) or TC/HDL ratios. On this evidence we do not consider that thyroxine replacement therapy is indicated in patients with subclinical hypothyroidism.
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
December 1981,
The Journal of clinical endocrinology and metabolism,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
November 2006,
Journal of the European Academy of Dermatology and Venereology : JEADV,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
July 1984,
Annals of internal medicine,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
May 2016,
Acta pharmacologica Sinica,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
December 1996,
Endocrine journal,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
October 1990,
Clinical endocrinology,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
June 2020,
Annals of internal medicine,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
April 2020,
Obstetrics and gynecology,
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
July 1994,
Internal medicine (Tokyo, Japan),
G M Bell, and
W T Todd, and
J C Forfar, and
C Martyn, and
C G Wathen, and
S Gow, and
R Riemersma, and
A D Toft
October 2003,
Pediatrics international : official journal of the Japan Pediatric Society,
