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The effect of propranolol on systemic and hepatic hemodynamics was studied in patients with cirrhosis. One hour after 40 mg propranolol by mouth as well as during continuous oral dosing at doses that reduced heart rate 25%, cardiac output and the hepatic venous pressure gradient fell significantly, whereas arterial pressure and hepatic blood flow did not change significantly. In six patients with cirrhosis and surgical end-to-side portacaval shunts, cardiac output and the hepatic venous pressure gradient also decreased 15 minutes after intravenous propranolol (5 mg), whereas hepatic blood flow did not change significantly. In the patients with surgical shunts, systemic vascular resistance rose significantly but hepatic arterial vascular resistance fell. Our data show that in patients with cirrhosis, propranolol induces an increase in the fraction of cardiac output reaching the liver.
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
September 1989,
Hepatology (Baltimore, Md.),
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
January 1992,
European journal of clinical pharmacology,
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
September 1992,
Digestive diseases and sciences,
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
January 1984,
Gastroenterology,
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
January 1984,
Hepatology (Baltimore, Md.),
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
August 1971,
Lancet (London, England),
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
July 1982,
Clinical science (London, England : 1979),
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
July 1999,
Clinical nuclear medicine,
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
February 1968,
Giornale di clinica medica,
A Braillon, and
M I Jirón, and
D Valla, and
P Calès, and
D Lebrec
January 1987,
Minerva dietologica e gastroenterologica,
