-transparent.png){kind=logo}
The action of partly purified neuraminidase (NA) of influenza A virus, a mixture of detergent solubilized NA and haemagglutinin (HA) and of intact virions on gangliosides GT1b, GD1a, GD1b, GM1 was studied. The viral NA transformed GT1b mainly into GD1b with formation of only minor amounts of GM1. HA was found to inhibit the hydrolysis activity of viral NA. At the same time viral NA transformed GD1a quantitatively into GM1 which was not hydrolyzed by the enzyme. These results suggest that the function of NA is to transfer the 'primary' receptor (such as GT1b) into the proper carbohydrate sequence (GD1b-like) which is proposed to serve as the minimal structure required for influenza virus reception.
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
January 2002,
Reviews in medical virology,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
February 2009,
Antiviral research,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
June 2009,
Biologicals : journal of the International Association of Biological Standardization,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
March 1970,
The Journal of general virology,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
September 1980,
Biochimica et biophysica acta,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
October 1968,
Biochimica et biophysica acta,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
May 2008,
Journal of virology,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
March 1989,
Acta virologica,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
June 1976,
Postgraduate medical journal,
V A Slepushkin, and
A G Bukrinskaya, and
N V Prokazova, and
L S Zhigis, and
P D Reshetov, and
J I Shaposhnikova, and
L D Bergelson
July 1963,
Journal of neurochemistry,
