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Two homozygous and heterozygous ataxia telangiectasia (AT) cell strains were compared to normal human cells for heat and radiation responses. The thermal sensitivities to one hour heating at 42.0 degrees C were comparable in the five cell strains. Thermal enhancement of radiosensitivity occurred in both homo- and hetero-zygous AT cell strains and was comparable to the thermal enhancement observed in the normal cell strain. Normal cells recovered during incubation at 37.0 degrees C between the two treatments of heat and X rays while homozygous AT cells showed no recovery. The heterozygous cell strains showed only a slight sequence dependence for heat and radiation sensitivity.
G P Raaphorst, and
E I Azzam
May 1983,
Mutation research,
G P Raaphorst, and
E I Azzam
October 1989,
Mutation research,
G P Raaphorst, and
E I Azzam
January 1982,
Carcinogenesis,
G P Raaphorst, and
E I Azzam
November 1992,
Mutation research,
G P Raaphorst, and
E I Azzam
August 1985,
Mutation research,
G P Raaphorst, and
E I Azzam
September 1984,
Radiation research,
G P Raaphorst, and
E I Azzam
August 1985,
Mutation research,
G P Raaphorst, and
E I Azzam
May 2000,
Radiation research,
G P Raaphorst, and
E I Azzam
March 1989,
Mutation research,
G P Raaphorst, and
E I Azzam
January 1981,
Mutation research,
