A new universal radiolucent handle is described that permits needle placement under continuous fluoroscopic observation, while maintaining the operator's hands outside the primary beam. The handle accommodates nearly all needles used for biopsy, anesthesia, nephrostomy, cholangiography, and biliary drainage, which represents a major advantage over previously described radiolucent handles. Reduced operator-hand exposures, improved needle guidance, and quick handle release are also major advantages of the universal handle. It is inexpensive, reliable, and reusable.