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Natural killer cell cytotoxicity was studied in a 18-hour 51Cr-release assay in the cultures of human tumor target cells: K562 leukemia and lung adenocarcinoma (LAC) cells. The mean cytotoxic value was similar for K562 and LAC cells: 36.13 +/- 3.23% and 40.78 +/- 3.43%, respectively, although significant individual variability was recorded. The similar cytolytic action of blood mononuclear cells (MNC) on the two tumor lines was observed in 30% of normal donors. MNC from 30% donors produced more pronounced lytic action on K562 cells while MNC from other 30% donors lysed mainly LAC cells. In the competitive inhibition test cold K562 cells more effectively than cold LAC cells suppressed the MNC-induced lysis of both K562 and LAC cells.
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E A Timofeevskaia, and
S G Osipov
January 1991,
Toxicology in vitro : an international journal published in association with BIBRA,
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S G Osipov
January 1984,
Farmakologiia i toksikologiia,
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October 1990,
Radiation research,
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S G Osipov
January 1986,
Pathology and immunopathology research,
G I Avdeev, and
M M Viadro, and
Iu D Leĭkin, and
E A Timofeevskaia, and
S G Osipov
December 1987,
Immunobiology,
G I Avdeev, and
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S G Osipov
December 1983,
Proceedings of the National Academy of Sciences of the United States of America,
G I Avdeev, and
M M Viadro, and
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December 1999,
Blood,
G I Avdeev, and
M M Viadro, and
Iu D Leĭkin, and
E A Timofeevskaia, and
S G Osipov
January 1986,
Immunologic research,
G I Avdeev, and
M M Viadro, and
Iu D Leĭkin, and
E A Timofeevskaia, and
S G Osipov
August 1985,
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G I Avdeev, and
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S G Osipov
February 2013,
Blood,
