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A radiolabeled monoclonal antibody (96.5) reactive with an Mr 97,000 antigen found on over 80% of melanoma cell lines and tissue extracts was examined for its ability to detect malignant melanoma metastases in vivo. For imaging purposes, it was conjugated with diethyltriaminepentaacetic acid and subsequently labeled with 111In by chelation. Thirty-one patients with metastatic melanoma received single injections of monoclonal antibody 96.5 at concentrations ranging from 0.5 to 20 mg and at specific activities of 111In ranging from 0.125 to 4 mCi/mg. Total-body scans were performed at various time intervals following administration. No serious side effects were observed. Of a total of 100 previously documented metastatic sites, 50 imaged for a specificity of 50%. The number of sites imaged increased significantly as the amount of antibody administered increased relative to the average radiation dose. Considerable background uptake of isotope was observed in blood pool and other organs with gradual acquisition of label in tumor sites by 48 to 72 h. Hence, tumor imaging of melanoma using 111In-labeled monoclonal antibody 96.5 appeared feasible, especially at antibody doses above 2 mg.
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
April 1989,
Gan to kagaku ryoho. Cancer & chemotherapy,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
December 1989,
Kaku igaku. The Japanese journal of nuclear medicine,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
November 1986,
Kaku igaku. The Japanese journal of nuclear medicine,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
June 1987,
The Journal of dermatology,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
January 1988,
Oncology,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
January 1990,
Acta oncologica (Stockholm, Sweden),
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
August 1998,
World journal of gastroenterology,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
January 1993,
Acta oncologica (Stockholm, Sweden),
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
July 1998,
Zhonghua yi xue za zhi,
J L Murray, and
M G Rosenblum, and
R E Sobol, and
R M Bartholomew, and
C E Plager, and
T P Haynie, and
M F Jahns, and
H J Glenn, and
L Lamki, and
R S Benjamin
February 1990,
Cancer research,
