BIOMAT Database Logo BIOMAT Database Logo

[Differential therapy with calcium antagonists. Hemodynamic studies using nifedipine, verapamil and diltiazem]. 1985

H U Lehmann, and H Hochrein

The haemodynamic effects of nifedipine, verapamil and diltiazem were measured and compared in an open randomized parallel investigation on 44 patients with coronary heart disease and compensated myocardial function. Each set of parameters was measured during a control phase and serially after a single dose (nifedipine in retard form, 20 mg; verapamil, 160 mg; diltiazem, 120 mg) over a period of 180 minutes at rest and after a standardized exercise. All three drugs produced a significant fall in systemic arterial pressure of 10-14% and of left-ventricular stroke work of 10-20% from the initial level. The main differences between the three drugs concerned heart rate and stroke volume. Nifedipine produced a significant rise in heart rate, while it fell by 8-10% below the control value after verapamil and diltiazem. On the other hand, verapamil caused a significant fall in stroke-volume index, while after nifedipine and diltiazem it remained unchanged. These results suggest differential therapeutic use of the various calcium antagonists.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009543 Nifedipine A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Adalat,BAY-a-1040,Bay-1040,Cordipin,Cordipine,Corinfar,Fenigidin,Korinfar,Nifangin,Nifedipine Monohydrochloride,Nifedipine-GTIS,Procardia,Procardia XL,Vascard,BAY a 1040,BAYa1040,Bay 1040,Bay1040,Monohydrochloride, Nifedipine,Nifedipine GTIS
D011669 Pulmonary Wedge Pressure The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES. Pulmonary Artery Wedge Pressure,Pulmonary Capillary Wedge Pressure,Pulmonary Venous Wedge Pressure,Wedge Pressure,Pressure, Pulmonary Wedge,Pressures, Pulmonary Wedge,Pulmonary Wedge Pressures,Wedge Pressure, Pulmonary,Wedge Pressures, Pulmonary,Pressure, Wedge,Pressures, Wedge,Wedge Pressures
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium
D003327 Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D004110 Diltiazem A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions. Aldizem,CRD-401,Cardil,Cardizem,Dilacor,Dilacor XR,Dilren,Diltiazem Hydrochloride,Diltiazem Malate,Dilzem,Tiazac,CRD 401,CRD401
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

H U Lehmann, and H Hochrein
Differential therapy with calcium antagonists in pulmonary hypertension secondary to COPD. Hemodynamic effects of nifedipine, diltiazem, and verapamil.
October 1990, Chest,
H U Lehmann, and H Hochrein
Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem.
December 1980, The American journal of cardiology,
H U Lehmann, and H Hochrein
Poisoning due to calcium antagonists. Experience with verapamil, diltiazem and nifedipine.
January 1991, Drug safety,
H U Lehmann, and H Hochrein
Calcium antagonists and calmodulin: effect of verapamil, nifedipine and diltiazem.
May 1983, European journal of pharmacology,
H U Lehmann, and H Hochrein
Facilitation of Neuromuscular transmission by calcium antagonists, diltiazem, nifedipine and verapamil, in the dog.
February 1981, Archives internationales de pharmacodynamie et de therapie,
H U Lehmann, and H Hochrein
Comparative effects of three calcium antagonists, diltiazem, verapamil and nifedipine, on the sinoatrial and atrioventricular nodes. Experimental and clinical studies.
May 1981, Circulation,
H U Lehmann, and H Hochrein
Negative inotropic activity of the calcium antagonists isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardium.
February 1991, American journal of hypertension,
H U Lehmann, and H Hochrein
[Comparative effects of three calcium antagonists (nifedipine, verapamil and diltiazem) on hemodynamics in recent myocardial infarction].
February 1985, Kokyu to junkan. Respiration & circulation,
H U Lehmann, and H Hochrein
[Anticholinesterase effect of calcium channel blockers: diltiazem, verapamil, and nifedipine].
March 1998, Doklady Akademii nauk,
H U Lehmann, and H Hochrein
[Comparison of the anti-angina effect of the calcium antagonists diltiazem, nifedipine and verapamil with each other and with propranolol].
January 1987, Revista espanola de cardiologia,
Copied contents to your clipboard!