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The objectives of these investigations were to study the absorption and disposition characteristics of felodipine in young healthy male volunteers following acute administration of different intravenous and oral doses, and to study urinary metabolites of [14C]felodipine following oral administration. Felodipine is rapidly and extensively absorbed from the gastrointestinal tract but owing to presystemic elimination, probably primarily in the liver, only 15% on average is systemically available. The systemic availability is independent of the oral dose in the 5 to 40 mg dose interval. The major fraction of the felodipine dose is localised extravascularly with a volume of distribution of about 10 L/kg. Less than 1% is confined to the blood. Felodipine is extensively bound to plasma proteins (greater than 99%). The mean elimination half-life of felodipine is greater than 10 hours. The urinary metabolic pattern of felodipine, using high pressure liquid chromatography, reveals 3 major metabolites (carboxylic acids of oxidised felodipine) in human urine.
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
April 1968,
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
November 1961,
British journal of anaesthesia,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
January 1989,
European journal of clinical pharmacology,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
May 1967,
Arzneimittel-Forschung,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
May 1956,
La Semana medica,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
May 1956,
La Semana medica,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
March 1967,
Annals of the New York Academy of Sciences,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
May 1956,
La Semana medica,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
March 1952,
Pracovni lekarstvi,
B Edgar, and
K J Hoffmann, and
P Lundborg, and
C G Regårdh, and
O Rönn, and
L Weidolf
September 1953,
Pracovni lekarstvi,
