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Within 9 months we observed intestinal perforations in three very low birth weight (VLBW) infants undergoing indomethacin treatment for symptomatic patent ductus arteriosus (sPDA). The three patients exhibited striking similarities in their clinical courses and predisposing factors. Although clinical and histological criteria did not differentiate the perforations from necrotising enterocolitis (NEC), a well-known entity in premature infants, these events were remarkable to us since we had observed no other cases of NEC in recent years. From animal experiments and pathophysiological data, a role for indomethacin in gastrointestinal ischaemic damage must be considered. This communication is not meant to discredit indomethacin treatment. However, awareness of potential complications and careful monitoring during treatment is warranted.
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
April 1989,
Journal of pediatric surgery,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
January 2021,
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G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
January 1953,
Pediatria pratica,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
January 2002,
Journal of perinatology : official journal of the California Perinatal Association,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
January 1999,
Zeitschrift fur Geburtshilfe und Neonatologie,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
May 2021,
The Journal of pediatrics,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
December 1986,
Helvetica paediatrica acta,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
October 1998,
Journal of pediatric surgery,
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
January 1984,
British medical journal (Clinical research ed.),
G Kühl, and
L Wille, and
M Bolkenius, and
H W Seyberth
December 1983,
British medical journal (Clinical research ed.),
