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The distribution of cefuroxime (250 mg) was studied in patients with renal failure undergoing continuous ambulatory peritoneal dialysis (CAPD). 10 uninfected patients received the drug intravenously and intraperitoneally, while 9 patients with peritonitis were randomly allocated to intravenous or intraperitoneal administration. Samples were taken over the first 6 hour dialysis period. In the infected patients, more drug (p less than 0.01) crossed into the peritoneal cavity following intravenous injection and reached the systemic circulation following intraperitoneal administration than in the uninfected group. This increased permeability of the peritoneal membrane during infection may result in unexpected systemic toxicity in patients treated with intraperitoneal antibiotics.
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
February 1988,
British journal of clinical practice. Supplement,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
January 1985,
American journal of diseases of children (1960),
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
May 1983,
Pediatrics,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
February 1990,
Clinical pharmacy,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
May 1987,
The Journal of hospital infection,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
August 1985,
Ugeskrift for laeger,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
August 1983,
The American journal of medicine,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
September 2011,
Journal of infection in developing countries,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
April 1993,
Enfermedades infecciosas y microbiologia clinica,
M E McIntosh, and
W G Smith, and
B J Junor, and
G Forrest, and
M J Brodie
June 1990,
The American journal of medicine,
