-transparent.png){kind=logo}
Six volunteers, 25-41 years of age, were exposed for 6 hr on separate days to 50 and 10 ppm of CH3Cl. Blood and expired air CH3Cl concentrations reached an apparent plateau during the first hour of the exposure and were proportional to the exposure concentration. Consistent with previous reports, the volunteers could be separated into two discrete groups based on the differences observed in their blood and expired air CH3Cl concentrations. Both groups eliminated CH3Cl rapidly once the exposure was terminated, but CH3Cl was eliminated more rapidly by those volunteers with the lower blood and expired air CH3Cl concentrations. The existence of these two groups can be explained by a twofold difference in the rate at which they metabolized CH3Cl; however, this difference is of questionable toxicological significance. Urinary excretion of the putative metabolite S-methyl cysteine was not related to the exposure; thus, it is not a valid means of monitoring occupational exposure to CH3Cl.
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
May 1983,
Toxicology and applied pharmacology,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
October 2000,
Pharmacogenetics,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
March 1980,
Toxicology and applied pharmacology,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
November 1984,
Toxicology and applied pharmacology,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
August 1982,
Toxicology and applied pharmacology,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
October 2017,
Anesthesiology,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
June 2001,
Acta pharmacologica Sinica,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
February 1985,
British journal of clinical pharmacology,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
November 2012,
Anesthesia and analgesia,
R J Nolan, and
D L Rick, and
T D Landry, and
L P McCarty, and
G L Agin, and
J H Saunders
July 1997,
Journal of pharmaceutical sciences,
