Biomaterial Database

[The diastolic pressure-volume relationship of the left ventricle--evaluation of canine isovolumetric contracting left ventricle]. 1985

R Murakami

Isovolumetrically contracting left ventricle of the anesthetized dog was used to evaluate the end-diastolic pressure-volume relationship [LVEDP (P)-LVEDV (V) relationship (curve)] following changes in heart rate, ischemia and administration of beta-adrenergic blocking drug. At the same time, relaxation indices were also obtained. Initial left ventricular volume was set at the end-diastolic pressure of 2.0 mmHg. Comparison of each parameters after intervention was done when each initial left ventricular volume was increased by 10 ml. With increase in heart rate, LVEDP increased significantly from 5.1 +/- 2.1 to 14.0 +/- 2.2 mmHg (at 160 bpm, p less than 0.02, vs 100 bpm) and to 24.0 +/- 1.0 mmHg (at 180 bpm, vs p less than 0.001, vs 100 bpm). Regional ischemia also increased LVEDP significantly from 6.4 +/- 1.4 mmHg to 12.8 +/- 4.1 mmHg (after 30 min, p less than 0.01, vs control) and to 14.1 +/- 4.7 mmHg (after 45 min, p less than 0.01, vs control). However, global ischemia produced by decreasing coronary perfusion pressure to 50 mmHg, or administration of propranolol (1.0 mg/kg) brought about no significant changes in LVEDP. Among the relaxation indices, peak negative dp/dt decreased significantly following global ischemia, regional ischemia and administration of propranolol (from 1101 +/- 131 to 733 +/- 49 mmHg/sec, p less than 0.01, from 888 +/- 425 to 268 +/- 94 mmHg/sec after 45 min, p less than 0.01 and from 562 +/- 160 to 291 +/- 100 mmHg/sec, p less than 0.01, respectively). On the other hand, time constant (T) of the left ventricular pressure fall was prolonged significantly following regional ischemia from 44.7 +/- 5.2 to 72.0 +/- 8.6 msec (after 30 min, p less than 0.001) and 95.4 +/- 26.0 msec (after 30 min, p less than 0.001) and 95.4 +/- 26.0 msec (after 45 min, p less than 0.001). Therefore, it is concluded that LV diastolic compliance decreases by tachycardia (160 and 180 bpm) and regional ischemia, while the changes of the relaxation indices were not necessarily parallel to those of the LV compliance.

UI	MeSH Term	Description	Entries
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D011433	Propranolol	A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.	Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002306	Cardiac Volume	The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.	Heart Volume,Cardiac Volumes,Heart Volumes,Volume, Cardiac,Volume, Heart,Volumes, Cardiac,Volumes, Heart
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D016276	Ventricular Function	The hemodynamic and electrophysiological action of the HEART VENTRICLES.	Function, Ventricular,Functions, Ventricular,Ventricular Functions
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In