Ventilatory and plasma lactate response with different exercise protocols: a comparison of methods. 1985

T M McLellan

The purpose of this study was to compare the methods used to identify abrupt changes in ventilation or plasma lactate (LA) during exercise. Ten males randomly performed a 1-, 3-, and 5-min, 30-W incremental cycle ergometer test to fatigue. The first change in VE and VCO2 relative to VO2 (ventilation threshold, VT1) was determined from plots of VE, VE X VO2-1, and excess CO2 vs VO2. Data were also analyzed for a second change in VE (VT2) relative to both VCO2 and VO2 using plots of VE and VE X VCO2(-1) vs VO2 and semi-log plots of VE X VO2(-1) and VE X VCO2(-1) vs VO2. Arterialized blood samples were taken each 1.0, 1.5, or 2.5 min for the 1-, 3-, and 5-min tests, respectively, to determine the LA threshold (LT) and the onset of blood lactate accumulation (4 mM, OBLA) and 1, 2, 5, 7.5, and 10 min after all tests to calculate the individual anaerobic threshold (IAT). At weekly intervals, subjects also exercised for 10 min at eight different power outputs (W) to define the onset of plasma lactate accumulation (OPLA). Results showed that VO2max was significantly higher for the 1-min (3.88 l X min-1)vs the 3- or 5-min tests (3.65 l X min-1). With increasing W duration, VT1 from either VE or VE X VO2-1 vs VO2 were similar (1.77 vs 1.72 l X min-1) but significantly lower using excess CO2 (1.23 l X min-1) . VO2 at LT (1.62 l X min-1) and OPLA (1.73 l X min-1) were similar to VT1.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007773 Lactates Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008297 Male Males
D011659 Pulmonary Gas Exchange The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER. Exchange, Pulmonary Gas,Gas Exchange, Pulmonary
D012119 Respiration The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration ( Breathing
D004056 Differential Threshold The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold. Difference Limen,Just-Noticeable Difference,Weber-Fechner Law,Difference Limens,Difference, Just-Noticeable,Differences, Just-Noticeable,Differential Thresholds,Just Noticeable Difference,Just-Noticeable Differences,Law, Weber-Fechner,Limen, Difference,Limens, Difference,Threshold, Differential,Thresholds, Differential,Weber Fechner Law
D005082 Physical Exertion Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included. Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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