-transparent.png){kind=logo}
A study of maternal-infant transmission of hepatitis B virus (HBV) was conducted in Singapore between June 1980 and June 1982. HBsAg carrier rate was highest among Chinese (6.2%) followed by Malay (2.3%) and Indian (0.6%) mothers. The presence of HBeAg in maternal sera correlated well with high titre HBsAg (p = 7.34 X 10(-5)). Overall HBV transmission occurred in 27/56 (48.2%) infants from carrier mothers. The majority of the transmission was perinatal. There was a very strong correlation between transmission and HBeAg status of the mother (p = 1.85 X 10(-9); odds ratio = 68.44) and to a lesser extent with high titre HBsAg (p = 0.002; odds ratio = 6.38). A strong negative correlation was seen between transmission and anti-HBeAg (p = 8.19 X 10(-7); odds ratio = 0.04). At one year 19 (70.4%) infants were still HBsAg positive while seven (25.9%) lost the antigenemia and acquired anti-HBsAg and one developed HBsAg after one year. It could be calculated that perinatal HBV transmission contributed about 18% to the total pool of HBsAg positive infants of one year of age.
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
November 2023,
Clinics in liver disease,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
October 2007,
Annals of the Academy of Medicine, Singapore,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
April 1989,
Lancet (London, England),
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
July 2014,
HIV medicine,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
January 1996,
Gut,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
November 1978,
The Journal of infectious diseases,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
December 1989,
Cancer,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
April 2021,
Vaccines,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
March 1977,
The New England journal of medicine,
S H Chan, and
K L Tan, and
K T Goh, and
C Lim, and
M Tsakok, and
C J Oon, and
S S Ratnam
August 2019,
The Journal of infectious diseases,
