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An animal model of partial hepatic artery occlusion and radiofrequency (RF)-induced hepatic hyperthermia was developed in the New Zealand white rabbit. Seventy-seven percent (10/13) of animals survived partial hepatic artery occlusion, 82% (41/50) survived RF-induced hepatic hyperthermia, and 66% (24/36) survived combined occlusion-hyperthermia. Mesenteric infarction secondary to inadvertent embolization of intestinal arteries was the principal cause of death in animals undergoing partial hepatic artery occlusion. Extrahepatic thermal toxicity appeared to be the major cause of death in animals subjected to hepatic hyperthermia or occlusion hyperthermia although some animals showed evidence of hepatic necrosis as well. Recent developments in our laboratory hold the promise that extrahepatic thermal toxicity can be eliminated by selectively focusing heat into the liver allowing exploration of the efficacy of occlusion-hyperthermia in controlling VX-2 tumors implanted in the rabbit liver.
A W Boddie, and
K Wright, and
L C Stephens, and
W S Yamanashi, and
J Frazer, and
C M McBride, and
S Wallace, and
R G Martin
July 1992,
Journal of applied physiology (Bethesda, Md. : 1985),
A W Boddie, and
K Wright, and
L C Stephens, and
W S Yamanashi, and
J Frazer, and
C M McBride, and
S Wallace, and
R G Martin
October 2010,
Neuroscience letters,
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R G Martin
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NMR in biomedicine,
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March 2004,
Pharmacopsychiatry,
A W Boddie, and
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November 1954,
Rivista di patologia e clinica,
A W Boddie, and
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July 2003,
Neurochemistry international,
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January 1998,
Transplant international : official journal of the European Society for Organ Transplantation,
A W Boddie, and
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R G Martin
June 1991,
International journal of radiation oncology, biology, physics,
A W Boddie, and
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April 2002,
The Journal of surgical research,
A W Boddie, and
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January 1989,
In vivo (Athens, Greece),
