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The concentration of cefoxitin (CFX, Merxin) in dead space exudate was studied in 14 patients following total extirpation of diffuse uterine cervical cancer. A two-compartment model was used for the analysis. The results obtained were as follows: Calculated maximum concentrations of CFX in the pelvic dead space exudate were 26.55 micrograms/ml at 2.11 hours, 31.07 micrograms/mg at 2.01 hours and 51.51 micrograms/ml at 2.10 hours after 1 hour intravenous drip infusions of CFX 2, 3 and 4 g, respectively. These concentrations were higher than the MIC80 of 12.5 micrograms/ml against E. coli and B. fragilis and were maintained for a sufficient period of time. Based on the results of this study, CFX is considered to be an important and valuable drug in the field of obstetrics and gynecology.
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
February 1985,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
August 1985,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
August 1985,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
December 1985,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
October 1982,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
September 1982,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
January 1984,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
December 1984,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
December 1984,
The Japanese journal of antibiotics,
K Ito, and
K Matsunami, and
M Hayasaki, and
K Noda
August 1985,
The Japanese journal of antibiotics,
