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A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation. Levodopa antagonizes the oxotremorine-induced cerebral symptoms (akinesia + tremor); however this antagonism disappears when mice are chronically pretreated orally with CDP-choline, confirming the action of CDP-choline on dopaminergic pathways. The proven efficacy of CDP-choline in Parkinsonism could then be mediated by a hypersensitivity of some cerebral dopamine receptors, and not by a direct stimulating effect of the striatal dopaminergic receptors.
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 1978,
Psychopharmacology,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
October 1972,
Canadian journal of biochemistry,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
August 2003,
Pharmacology, biochemistry, and behavior,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 1971,
Journal de physiologie,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 2018,
Journal of neuroendocrinology,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 1983,
Psychopharmacology,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 2015,
Brain research,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 2000,
Annals of the New York Academy of Sciences,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 1989,
Rivista di neurologia,
C Saligaut, and
M Daoust, and
M Chadelaud, and
N Moore, and
P Chretien, and
F Boismare
January 2005,
Neurochemical research,
