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Endotoxin (1 mg/kg, I.P.) greatly reduces lung damage and pleural edema in rats exposed to greater than 99% oxygen. Endotoxin also activates and depletes complement in vitro. Prior in vivo complement depletion has been shown to protect rats from lung edema in some experimental models. This study was designed to evaluate the possibility that endotoxin may protect rats from oxygen toxicity by activating and thereby depleting complement. We found no significant changes in complement hemolytic activity in serum from endotoxin pretreated rats breathing greater than 99% oxygen at sea level for 60 hours. We also found that complement depletion prior to oxygen exposure failed to protect rats from the lung damage of oxygen toxicity. These results indicate that the mechanism of endotoxin protection from pulmonary oxygen toxicity does not involve complement.
J T Berg, and
R M Smith
February 1990,
Journal of applied physiology (Bethesda, Md. : 1985),
J T Berg, and
R M Smith
October 2002,
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J T Berg, and
R M Smith
February 1978,
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J T Berg, and
R M Smith
January 1987,
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J T Berg, and
R M Smith
November 1967,
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J T Berg, and
R M Smith
November 1971,
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J T Berg, and
R M Smith
March 1989,
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J T Berg, and
R M Smith
March 1985,
Journal of applied physiology (Bethesda, Md. : 1985),
J T Berg, and
R M Smith
September 1979,
Toxicology and applied pharmacology,
J T Berg, and
R M Smith
January 1985,
Advances in experimental medicine and biology,
