-transparent.png){kind=logo}
Five hundred and seventy-four ambulatory subjects with blood pressures ranging from 94/58 to 250/145 mm Hg were studied on their usual dietary and sodium intake. Renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium were compared with blood pressure to access the contribution of these variables to the blood pressure variance. Our analyses revealed that renin substrate was highly and positively correlated with diastolic blood pressure (r = +0.39; p < 0.00001) but all other components of the renin-aldosterone system exhibited a significant negative correlation with blood pressure. A highly significant relationship between potassium, the renin-aldosterone system and blood pressure was found but no such relationship could be demonstrated for sodium. Subjects with higher blood pressures had lower urinary potassium concentrations and lower potassium/creatine ratios. These findings raised the possibility of a significant pathogenetic relationship between potassium and high blood pressure. Multiple linear regression reveals that influences of the renin-angiotensin-aldosterone system can only account for less than 20% of the variance exhibited by the blood pressure in these subjects.
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
January 1982,
Acta medica Scandinavica,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
December 1980,
Clinical science (London, England : 1979),
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
January 1972,
Journal d'urologie et de nephrologie,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
January 1975,
The Journal of clinical endocrinology and metabolism,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
May 1968,
Zeitschrift fur Kreislaufforschung,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
January 1991,
The American journal of cardiology,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
April 1986,
Postgraduate medical journal,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
November 2008,
Expert opinion on therapeutic targets,
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
December 1981,
Clinical science (London, England : 1979),
W G Walker, and
P K Whelton, and
H Saito, and
R P Russell, and
J Hermann
September 1983,
Arquivos brasileiros de cardiologia,
