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Density-dependence of maximal expiratory flow was measured in 110 patients prior to resection for peripheral coin lesions. The resected lung or lobe was examined morphologically and graded for emphysema, membranous bronchiolitis, and respiratory bronchiolitis. Density dependence did not decrease with increasing airway obstruction, and there was no relationship between density-dependence and peripheral airway abnormality or emphysema in the group as a whole. When patients were arbitrarily divided into those with forced expiratory volume in one second (FEV1) greater than 80% predicted (n = 80) and FEV1 less than 80% predicted (n = 30), density-dependence correlated significantly and negatively with membranous bronchiolitis in those with FEV1 greater than 80% predicted and significantly but positively in those with more advanced airway obstruction. We conclude that density-dependence of maximal expiratory flow is not an accurate predictor of peripheral airway abnormality in patients with mild to moderate air-flow obstruction.
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
January 1980,
The American review of respiratory disease,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
March 1987,
The American review of respiratory disease,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
April 1982,
Journal of applied physiology: respiratory, environmental and exercise physiology,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
November 1980,
Journal of applied physiology: respiratory, environmental and exercise physiology,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
August 1982,
Journal of applied physiology: respiratory, environmental and exercise physiology,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
July 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
October 1980,
The American review of respiratory disease,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
August 1976,
Clinical science and molecular medicine,
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
March 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
P D Paré, and
L A Brooks, and
C A Coppin, and
J L Wright, and
S Kennedy, and
R Dahlby, and
S Mink, and
J C Hogg
April 1983,
Respiration physiology,
