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The dimeric hemoglobin (HbI) from Scapharca inaequivalvis is highly homologous to the other known dimeric Acid hemoglobins. The sequence has a distinctive hydrophobicity profile in the region corresponding to the E and F helices with respect to both the hemoglobin and myoglobin chains from vertebrates due to the presence of several additional hydrophobic residues. The characteristic topology of the E and F helices is conserved in all the known sequences of Arcid hemoglobins including that of the so-called alpha chain of the tetrameric component from Anadara trapezia. The rationale for this conservation lies in the unusual assembly of Arcid hemoglobins where the E and F helices are involved in the interdimeric contact. It is suggested that the extra hydrophobic residues play a major role in the assembly of the basic dimeric unit in these hemoglobins.
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
January 1982,
Advances in experimental medicine and biology,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
September 1989,
European journal of biochemistry,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
December 1999,
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
August 2000,
Biophysical chemistry,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
September 1993,
FEBS letters,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
April 1997,
Biochemistry,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
December 1996,
Biochimica et biophysica acta,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
October 1994,
Biophysical journal,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
June 1984,
The Journal of biological chemistry,
R Petruzzelli, and
B M Goffredo, and
D Barra, and
F Bossa, and
A Boffi, and
D Verzili, and
F Ascoli, and
E Chiancone
February 1996,
The Journal of biological chemistry,
