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Rat thymocytes were stimulated with phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) or with mixtures of two of these mitogens, added simultaneously to in vitro cultures. Four-five concentrations of first mitogen were matched with four-five concentrations of second mitogen, in all possible combinations. Synergistic effects were observed with LPS plus PHA and LPS plus PWM and inhibitory effects with PHA plus Con A and LPS plus Con A. The hypothesis is discussed that an inhibitory effects occurs when two mitogens react with identical or very similar receptors on the lymphocyte surface, while a synergistic effect is produced by two mitogens reacting with different receptors.
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
July 1972,
The Journal of experimental medicine,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
October 1975,
Journal of the Reticuloendothelial Society,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
January 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
July 1972,
The Journal of experimental medicine,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
September 1982,
Arerugi = [Allergy],
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
March 1974,
Cellular immunology,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
May 1977,
Cellular immunology,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
January 1985,
European journal of clinical pharmacology,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
January 1976,
International archives of allergy and applied immunology,
C Franceschi, and
C Cevolani, and
F Licastro, and
P Paolucci, and
G Prodi, and
P Perocco
February 1977,
Cellular immunology,
