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From March, 1976 to February, 1979, 28 cases of adult acute leukemia of which 24 were evaluable were treated in irreversible relapse with high dose chemotherapy (piperazinedione) and supra-lethal total body irradiation (TBI) in conjunction with autologous bone marrow transplantation (ABMT). The marrow cells grafted were collected and stored in liquid nitrogen at the time of remission. In 12 patients the marrow cells were fractionated using discontinuous albumin gradients in an attempt to separate normal cells from residual leukemic cells. Twelve patients achieved complete remission (CR); in 9 additional patients signs of engraftment were evident but death occurred before achievement of CR. Seven of 12 AML patients, which were treated with bone marrow transplantation as first treatment of their relapse, achieved CR. Four of 5 patients with ALL, whose bone marrows were collected during first remission, reached CR. The median CR duration was 4+ months and the median survival of the patients reaching CR was 6+ months. Autologous bone marrow transplantation offers a good chance of CR (66%), when marrow is collected during first remission and used as first treatment for AML in third relapse and ALL in second relapse.
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
February 1993,
Hematology/oncology clinics of North America,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
August 1987,
European journal of haematology,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
June 1986,
Journal of the National Cancer Institute,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
January 1987,
Acta haematologica,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
October 1999,
Hematology/oncology clinics of North America,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
January 2003,
Leukemia & lymphoma,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
March 1977,
Transplantation proceedings,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
February 1991,
Zhonghua nei ke za zhi,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
April 1991,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
K A Dicke, and
A R Zander, and
G Spitzer, and
D S Verma, and
L J Peters, and
L Vellekoop, and
S Thomson, and
D Stewart, and
J P Hester, and
K B McCredie
July 1996,
Human gene therapy,
