Biomaterial Database

Problems with ethical aspects of psychotropic drug use. 1979

H E Lehmann

Department of Psychiatry, McGill University, Montreal, Canada.

1. Research is an important area within the purview of medical ethics. The Nuremberg Code and the Helsinki Declaration provide well established guidelines in this field. 2. Specific ethical issues still requiring clarification in psychopharmacological research are the informed consent, the benefit/risk ratio and the choice of placebo or standard. 3. Peer review committees, if well chosen for their objectivity, general competence and special expertise, are likely to be the best arbiters regarding such questions. 4. Legislation and other political interventions--unfortunately not always objective, competent or expert in the exercise of their powers--have recently developed into rampant paraethical problems that are plaguing medical treatment and research in many parts of the world and need to be dealt with urgently through internationally coordinated efforts. The WHO would appear to be the most appropriate agency for such action.

UI	MeSH Term	Description	Entries
D011619	Psychotropic Drugs	A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).	Psychoactive Agent,Psychoactive Agents,Psychoactive Drug,Psychopharmaceutical,Psychopharmaceuticals,Psychotropic Drug,Psychoactive Drugs,Agent, Psychoactive,Agents, Psychoactive,Drug, Psychoactive,Drug, Psychotropic,Drugs, Psychoactive,Drugs, Psychotropic
D004992	Ethics, Medical	The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.	Medical Ethics
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D018570	Risk Assessment	The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)	Assessment, Risk,Benefit-Risk Assessment,Risk Analysis,Risk-Benefit Assessment,Health Risk Assessment,Risks and Benefits,Analysis, Risk,Assessment, Benefit-Risk,Assessment, Health Risk,Assessment, Risk-Benefit,Benefit Risk Assessment,Benefit-Risk Assessments,Benefits and Risks,Health Risk Assessments,Risk Analyses,Risk Assessment, Health,Risk Assessments,Risk Benefit Assessment,Risk-Benefit Assessments
D028642	Mentally Ill Persons	Persons with psychiatric illnesses or diseases, particularly psychotic and severe mood disorders.	Mental Patients,Mentally Ill,Ill, Mentally,Mentally Ill Person,Person, Mentally Ill,Persons, Mentally Ill
D028741	Ethics Committees, Clinical	Hospital or other institutional ethics committees established to consider the ethical dimensions of patient care. Distinguish from ETHICS COMMITTEES, RESEARCH, which are established to monitor the welfare of patients or healthy volunteers participating in research studies.	Clinical Ethics Committee,Clinical Ethics Committees,Committee, Clinical Ethics,Committee, Hospital Ethics,Committees, Clinical Ethics,Committees, Hospital Ethics,Ethics Committee, Clinical,Ethics Committee, Hospital,Ethics Committees, Hospital,Hospital Ethics Committee,Hospital Ethics Committees
D028744	Ethics Committees, Research	Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.	Institutional Review Boards,Board, Institutional Review,Boards, Institutional Review,Ethics Committee, Research,IRB,IRBs,Institutional Review Board,Research Ethics Committee,Research Ethics Committees,Review Board, Institutional,Review Boards, Institutional,Committee, Research Ethics,Committees, Research Ethics