-transparent.png){kind=logo}
1. Steady-state plasma level samples of sixty-five schizophrenic patients from two psychiatric hospitals assigned to three treatment groups (amitriptyline 150 mg/day, perphenazine 20 mg/day and a combination of amitriptyline and perphenazine at 150 mg and 20 mg/day) were assayed for amitriptyline (AT), endogenous nortriptyline (NT) and perphenazine (PPZ) using gas-liquid chromatography. 2. Results reveal that AT and NT levels are independent of sex and hospital environment. 3. PPZ significantly increased the steady-state NT plasma levels, probably through inhibition of the hydroxylation biotransformation pathway, but had no effect on AT levels, thus indicating that PPZ has no influence on the desmethylation pathway, or alternatively, the hydroxylation of AT.
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
December 1982,
Lancet (London, England),
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
October 1982,
The American journal of psychiatry,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
October 1975,
Archives of general psychiatry,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
March 1964,
Diseases of the nervous system,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
November 1964,
The American journal of psychiatry,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
October 1986,
Zeitschrift fur Gastroenterologie,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
January 1982,
Anaesthesia,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
January 1964,
Psychosomatics,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
January 1969,
Psychosomatics,
S F Cooper, and
R Dugal, and
R Elie, and
J M Albert
February 1967,
The British journal of psychiatry : the journal of mental science,
