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The effect of an acute nonspecific inflammatory exudate with mitogenic activity for macrophages in culture has been tested on the spontaneous and PHA-induced DNA synthesis by spleen cells in vitro. Stimulatory effect of this exudate was observed on the spontaneous DNA synthesis which was detectable over a range of 1:4 to 1:4096 concentrations. After optimal PHA stimulation, an inhibition of mitogen-induced DNA synthesis was observed when the cells were exposed to the highest concentrations (up to 1:128) of the exudate. Thereafter, the phenomenon could be reversed and the stimulation was maximal at the concentration of 1:2048. When a suboptimal dose of PHA was used, the stimulatory effect was more pronounced and detected from 1:8 up to 1:4096 concentrations.
I Florentin, and
M Pelletier, and
J P Giroud
January 1963,
The Journal of laboratory and clinical medicine,
I Florentin, and
M Pelletier, and
J P Giroud
July 1965,
American journal of ophthalmology,
I Florentin, and
M Pelletier, and
J P Giroud
January 1972,
Acta biologica Academiae Scientiarum Hungaricae,
I Florentin, and
M Pelletier, and
J P Giroud
May 1967,
Experientia,
I Florentin, and
M Pelletier, and
J P Giroud
February 1978,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
I Florentin, and
M Pelletier, and
J P Giroud
January 1978,
Digestion,
I Florentin, and
M Pelletier, and
J P Giroud
January 1978,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
I Florentin, and
M Pelletier, and
J P Giroud
August 1963,
Experimental cell research,
I Florentin, and
M Pelletier, and
J P Giroud
January 1974,
International archives of allergy and applied immunology,
I Florentin, and
M Pelletier, and
J P Giroud
November 1960,
Nature,
