Biomaterial Database

Dynamics of glomerular filtration in the river lamprey, Lampetra fluviatilis L. 1985

A J McVicar, and J C Rankin

Hydrostatic pressures decreased in the dorsal aorta (from 21.6 +/- 2.0 to 18.7 +/- 0.2 mmHg), proximal (from 19.5 +/- 1.6 to 16.2 +/- 1.7 mmHg) and distal (from 16.7 +/- 0.7 to 13.2 +/- 0.9 mmHg) renal arteries, and glomerular capillaries (from 16.1 +/- 1.1 to 12.3 +/- 0.6 mmHg) of anesthetized lampreys transferred from freshwater to isosmotic 20-30% seawater. Maximal vascular resistance appeared to be in the efferent arteriole; there was a 67% decrease in pressure between glomerular and peritubular capillaries. Plasma oncotic pressure was unchanged. The calculated afferent effective filtration pressure decreased by 87% after transfer and showed a good correlation with single nephron filtration rate. Effective renal plasma flow was high but variable in freshwater lampreys and decreased by 84% after transfer, but glomerular filtration rate did not decrease proportionately and there was a nonsignificant increase in mean filtration fraction from 0.045 +/- 0.022 to 0.080 +/- 0.021. Calculation of glomerular efferent oncotic pressure indicated that filtration equilibrium did not exist in freshwater lampreys but was attained after transfer. The mean coefficient of filtration of freshwater lampreys was 0.028 +/- 0.002 nl X s-1 X mmHg-1.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007678	Kidney Glomerulus	A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.	Glomerulus, Kidney
D007798	Lampreys	Common name for the only family (Petromyzontidae) of eellike fish in the order Petromyzontiformes. They are jawless but have a sucking mouth with horny teeth.	Eels, Lamprey,Petromyzontidae,Petromyzontiformes,Eel, Lamprey,Lamprey,Lamprey Eel,Lamprey Eels
D012079	Renal Circulation	The circulation of the BLOOD through the vessels of the KIDNEY.	Kidney Circulation,Renal Blood Flow,Circulation, Kidney,Circulation, Renal,Blood Flow, Renal,Flow, Renal Blood
D002200	Capillary Resistance	The vascular resistance to the flow of BLOOD through the CAPILLARIES portions of the peripheral vascular bed.	Capillary Resistances,Resistance, Capillary,Resistances, Capillary
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006874	Hydrostatic Pressure	The pressure due to the weight of fluid.	Hydrostatic Pressures,Pressure, Hydrostatic,Pressures, Hydrostatic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014655	Vascular Resistance	The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.	Peripheral Resistance,Total Peripheral Resistance,Pulmonary Vascular Resistance,Systemic Vascular Resistance,Peripheral Resistance, Total,Resistance, Peripheral,Resistance, Pulmonary Vascular,Resistance, Systemic Vascular,Resistance, Total Peripheral,Resistance, Vascular,Vascular Resistance, Pulmonary,Vascular Resistance, Systemic