Introduction Interprofessional communication between health care professionals is crucial to deliver quality health outcomes and enhance patients' quality of life. Aim This study aimed to investigate the perspectives and contents of the interprofessional communication between general dental practitioners (GDPs) and general medical practitioners (GPs), and to explore the barriers and strategies that could bridge the gap between these health care professionals from their perspectives. Methods A qualitative study approach was undertaken, with semi-structured interviews conducted with GDPs and GPs from Dunedin and Auckland, New Zealand. Transcripts were analysed using a thematic approach to identify patterns and main themes. Results Three major themes emerged from the interviews with GDPs (n =10) and GPs (n =6): (1) experiences of communication, (2) the content of communication and (3) barriers and suggestions to improve communication. Most GDP and GP participants reported that there was a lack of communication between these two specialties. Complex medical conditions and polypharmacy were the topics perceived as essential for interprofessional communication between GDPs and GPs. The barriers of communication included time constraints, insufficient knowledge of the dental field among most GPs, inadequate understanding of referral among GDPs, and the absence of a common means of communication. Discussion Both GDPs and GPs reported a lack of efficient interprofessional communication. They suggested implementing interprofessional education, integrating health record systems, scheduling regular face-to-face meetings, and developing effective referral guidelines.