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The lamellated periosteal reaction produced in the hind limbs of seven beagle puppies following ligation of the femoral vein was used as a model for studying the mechanism of lamellated new bone formation. Rather than resulting from alternating periods of slow and fast growth, this lamellated periosteal reaction was caused by acceleration of the normal process of periosteal bone growth. This involvement is thought to explain the "physiologic" periosteal new bone of early infancy.
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