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A panel of ten human bladder tumor cell lines were tested for drug sensitivity to ten standard or investigational anticancer drugs using a tumor colony assay. The activity of these anticancer agents in vitro was then compared with the clinical activity of these agents in bladder cancer. Drug activity was found in only five of the ten cell lines. In only 9 of 100 drug assays was the inhibition of colony growth lower than 30% of the controls. The activity of the more active anticancer drugs in bladder cancer (i.e., methotrexate and cisplatin) was not predicted using the tumor colony assay. Overall, the low level of activity of most anticancer drugs tested paralleled the clinical experience of drug resistance found in human bladder cancer.
H B Niell, and
K C Webster, and
E E Smith
April 1977,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
H B Niell, and
K C Webster, and
E E Smith
October 1992,
Gan to kagaku ryoho. Cancer & chemotherapy,
H B Niell, and
K C Webster, and
E E Smith
June 2017,
Medical science monitor : international medical journal of experimental and clinical research,
H B Niell, and
K C Webster, and
E E Smith
March 2002,
Ai zheng = Aizheng = Chinese journal of cancer,
H B Niell, and
K C Webster, and
E E Smith
January 1977,
Urological research,
H B Niell, and
K C Webster, and
E E Smith
August 1993,
The Journal of urology,
H B Niell, and
K C Webster, and
E E Smith
June 1992,
Cancer research,
H B Niell, and
K C Webster, and
E E Smith
March 2012,
International journal of biomedical science : IJBS,
H B Niell, and
K C Webster, and
E E Smith
January 1992,
Anticancer research,
H B Niell, and
K C Webster, and
E E Smith
January 1995,
Cancer chemotherapy and pharmacology,
