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In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow intravenous bolus dose of 200 mg cimetidine was given at the beginning of the last hour. Gastric secretion was measured before and after cimetidine administration and expressed both as mean acid output (mmol H+/h) and 'pyloric loss and duodenogastric reflux corrected' volume (Vg, ml/h). Mean reduction by acid output was 86%; mean reduction by corrected volume (Vg) was only 64%. The discrepancy, which is significant (p less than 0.01), is caused by a marked increase in duodenogastric reflux after cimetidine.
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
December 1982,
Gastroenterology,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
April 1987,
The British journal of surgery,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
November 1980,
Gut,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
October 1992,
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R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
December 1991,
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R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
October 1981,
The British journal of surgery,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
September 1983,
Scandinavian journal of gastroenterology,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
April 1981,
Australian and New Zealand journal of medicine,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
January 2002,
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association,
R J Melville, and
S I Suleiman, and
P F Whitfield, and
J V Parkin, and
T O Nwabunike, and
M Hobsley
March 1975,
Lancet (London, England),
