-transparent.png){kind=logo}
A patient with methylmalonic acidemia was found to have a persistent hyperchloremic acidosis. Investigation documented the presence of a proximal renal tubular acidosis. Between 14 and 18 months of age the urinary pH was as high as 8.0 when the serum bicarbonate was 17 mEq/liter and the threshold for bicarbonate was at 16-17 mEq/liter. When restudied at 33 months of age, the threshold had risen to 20 mEq/liter, but this was still abnormal and supplemental treatment was required to keep the serum concentration of bicarbonate above 20 mEq/liter. It is postulated that organic acid metabolites which accumulate in this and related disorders may interfere with renal tubular function as has been shown for maleic acid in experimental animals.
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
September 1998,
Pediatric nephrology (Berlin, Germany),
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
January 1977,
Revista chilena de pediatria,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
November 1972,
Proceedings of the Royal Society of Medicine,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
January 2006,
Journal of nephrology,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
January 2005,
Pediatric nephrology (Berlin, Germany),
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
January 1997,
Ryoikibetsu shokogun shirizu,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
February 1983,
Minerva pediatrica,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
June 2010,
Internal and emergency medicine,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
April 1978,
Helvetica paediatrica acta,
J A Wolff, and
C Strom, and
W Griswold, and
F Sweetman, and
S Kulovich, and
C Prodanos, and
W L Nyhan
January 2002,
Journal of nephrology,
