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Fifty-two children with clinical stages I-III Hodgkin's disease were evaluated for disease extent between April 1969 and March 1975. All underwent laparotomy and splenectomy. Two patients with liver involvement were excluded. Thirty of 31 patients with pathologically staged IA-IIA disease have been continuous complete remission after mantle and para-aortic irradiation. There have been no extensions into the untreated pelvis. Fourteen of 15 patients with pathologic stages IIB and IIIB disease show no evidence of relapse after TNI and MOPP. Three of four patients with stage IIIA disease developed nodal relapse after irradiation; all are alive without evidence of disease after re-irradiation (3) and MOPP (2). Thus 45 of 50 patients (90%) have remained continuously free of disease after completion of the planned treatment, and overall 49 of 50 (98%) are alive, without evidence of disease. Such results justify continuation of our staging and treatment philosophy in children with Hodgkin's disease.
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
January 1977,
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L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
May 1981,
Klinische Wochenschrift,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
December 1978,
Israel journal of medical sciences,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
January 1988,
Panminerva medica,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
January 1977,
Nouvelle revue francaise d'hematologie; blood cells,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
August 1986,
Helvetica paediatrica acta,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
July 1980,
The British journal of surgery,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
January 1978,
European journal of cancer,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
March 1979,
The New England journal of medicine,
L E Botnick, and
R Goodman, and
N Jaffe, and
R Filler, and
J R Cassady
January 1985,
Nowotwory,
