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Eleven healthy volunteers were examined in a pharmacokinetic study. After oral administration of 50 mg amitriptylinoxide or 50 mg amitriptyline the plasma levels of amitriptylinoxide and its main metabolites amitriptyline and nortriptyline were investigated over 24 hours. The results indicate that amitriptylinoxide is more rapidly absorbed than amitriptyline and eliminated with a mean half-life of 1.5 hours. The change with time in the levels of amitriptyline formed from the oxide is similar to that of amitriptyline after ingestion of amitriptyline. However, the plasma concentration of amitriptylinoxide, reflected by the area under the time curve (AUC), exceeds that of its metabolite amitriptyline twelvefold.
H J Kuss, and
G Jungkunz, and
K J Johannes
November 1988,
Pharmacopsychiatry,
H J Kuss, and
G Jungkunz, and
K J Johannes
January 1992,
Psychopharmacology,
H J Kuss, and
G Jungkunz, and
K J Johannes
January 1989,
Biopharmaceutics & drug disposition,
H J Kuss, and
G Jungkunz, and
K J Johannes
January 1986,
European journal of drug metabolism and pharmacokinetics,
H J Kuss, and
G Jungkunz, and
K J Johannes
November 1991,
Biopharmaceutics & drug disposition,
H J Kuss, and
G Jungkunz, and
K J Johannes
January 1982,
European journal of drug metabolism and pharmacokinetics,
H J Kuss, and
G Jungkunz, and
K J Johannes
April 1990,
The Journal of antimicrobial chemotherapy,
H J Kuss, and
G Jungkunz, and
K J Johannes
October 2004,
Drug metabolism reviews,
H J Kuss, and
G Jungkunz, and
K J Johannes
July 1984,
Journal of clinical pharmacology,
H J Kuss, and
G Jungkunz, and
K J Johannes
January 1983,
Pharmacopsychiatria,
