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The ability of inhaled atropine and clonidine to inhibit a bronchospasm produced by injected acetylcholine or by vagal stimulation, was studied in anaesthetized guinea pigs. Vagally mediated airway constriction was restrained in a concentration-related fashion by inhaled clonidine and reached nearly 100% inhibition (EC50 = 2 X 10(-5) mol/l in the nebulizer). Atropine expressed initially about the same level of spasmolytic effect but only a final prevention of 60% was possible to reach with this drug. On the contrary, inhaled atropine was able to produce a complete inhibition (EC50 = 2 X 10(-6) mol/l) when the bronchoconstriction was elicited by exogenous acetylcholine. This type of spasm was also to some degree inhibited by clonidine.
O A Olsson, and
A Ekdahl
May 1989,
British journal of pharmacology,
O A Olsson, and
A Ekdahl
June 1991,
The American review of respiratory disease,
O A Olsson, and
A Ekdahl
March 1984,
Acta physiologica Scandinavica,
O A Olsson, and
A Ekdahl
May 1991,
Anesthesia and analgesia,
O A Olsson, and
A Ekdahl
October 1993,
Japanese journal of pharmacology,
O A Olsson, and
A Ekdahl
July 1991,
The Journal of pharmacology and experimental therapeutics,
O A Olsson, and
A Ekdahl
October 1978,
British journal of pharmacology,
O A Olsson, and
A Ekdahl
January 1984,
Agents and actions,
O A Olsson, and
A Ekdahl
September 1952,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
O A Olsson, and
A Ekdahl
March 1977,
British journal of pharmacology,
