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The effect of 40 mg furosemide intravenously on sodium excretion, the renin-aldosterone system and arginine vasopressin (AVP) was studied in 14 patients with the nephrotic syndrome and in 13 control subjects. Creatinine clearance (Ccr) was reduced in all patients but four. Before furosemide, AVP, but not angiotensin II (AII) or aldosterone (Aldo), was increased in the nephrotic patients. After furosemide, sodium excretion (NaE) increased less and changes in AVP, AII and Aldo were blunted in the patients. Ccr and NaE were positively correlated in the nephrotic syndrome. The reduced sodium response after furosemide in the nephrotic syndrome seems to be closely correlated to a reduced glomerular filtration rate but not to an increased activity of the renin-angiotensin-aldosterone system. The reduced response of AVP, AII and Aldo after furosemide is consistent with a lower degree of volume depletion in nephrotic patients.
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
March 1967,
American journal of diseases of children (1960),
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
February 1950,
The American journal of physiology,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
September 1951,
The Journal of physiology,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
March 1956,
Quarterly review of surgery,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
August 1986,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
February 2011,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
December 1967,
The Yale journal of biology and medicine,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
January 1973,
Zeitschrift fur Versuchstierkunde,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
November 1991,
Clinical nephrology,
H Danielsen, and
E B Pedersen, and
M Madsen, and
T Jensen
April 1972,
British medical journal,
