Biomaterial Database

Evaluation of the zetacrit and zeta sedimentation ratio in dogs. 1985

D G Martin, and J E Hall, and D H Patrick

The Wintrobe erythrocyte sedimentation rate (ESR) has been used in animals and persons as a screening test for inflammatory disease and as a monitor for disease progression in individuals. Now, the zetacrit (ZC) and zeta sedimentation ratio (ZSR) are suggested as suitable rapid laboratory tests to replace the ESR in dogs. In 65 dogs, a strong inverse correlation between ESR and ZC was observed (r = -0.961, P less than 0.05). Significant correlations of similar magnitude between ZC and hematocrit (r = 0.587, P less than 0.05) and ESR and Hct (r = 0.569, P less than 0.05) were observed. In addition, influences of various protein fractions, such as fibrinogen, globulin, and albumin, on the ESR and ZC were evaluated and found to be of similar magnitude. These data indicate that ESR and ZC are equivalent methods for determining erythrocyte sedimentation rates in dogs. A strong correlation (r = 0.900, P less than 0.05) between Wintrobe ESR, adjusted for the effect of Hct (ESRHct), and ZSR was observed. The influence of plasma proteins on ESRHct and ZSR was of similar magnitude. However, a weak yet significant correlation between ESRHct and the microhematocrit remained (r = 0.291, P less than 0.05). Data indicate that the latter more effectively factors out the influence of Hct on sedimentation.

UI	MeSH Term	Description	Entries
D007249	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D001798	Blood Proteins	Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.	Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D001799	Blood Sedimentation	Measurement of rate of settling of ERYTHROCYTES in blood.	Erythrocyte Sedimentation,Erythrocyte Sedimentation Rate,Erythrocyte Sedimentation Rates,Rate, Erythrocyte Sedimentation,Rates, Erythrocyte Sedimentation,Sedimentation Rate, Erythrocyte,Sedimentation Rates, Erythrocyte,Sedimentation, Blood,Sedimentation, Erythrocyte
D004184	Dirofilariasis	Infection with nematodes of the genus DIROFILARIA, usually in animals, especially dogs, but occasionally in man.	Heartworm Disease,Dirofilariases,Disease, Heartworm
D004283	Dog Diseases	Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.	Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia